Steroid hormones are derived from cholesterol and synthesized in the adrenal cortex, the gonads, and the placenta. Most of them are clinical importance. The measuring of Steroid Panel, 5 Hormones [ i.e. 11-Deoxycortisol, 17-Hydroxyprogesterone (17-OHP), Androstenedione, Corticosterone and Dehydroepiandrosterone (DHEA)] is mainly used as a screening test for Congenital Adrenal Hyperplasia (CAH). CAH is caused by inherited defects in steroid biosynthesis and the diagnosis of CAH always requires the measurement of several steroid hormones simultaneously. Steroid panel, 5 hormones include.
11-Deoxycortisol is the immediate precursor of cortisol and is typically increased when Adrenocorticotropic hormone (ACTH) level is increased (e.g., Cushing’s syndrome, ACTH-producing tumors) or in 11 beta-Hydroxylase deficiency, a rare sub-form of CAH.
17-Hydroxyprogesterone (17-OHP) is a building block for producing the hormone cortisol. 17-OHP is one of the most excellent tests for CAH screening. Also, 17-OHP may be used as a part of newborn screening for monitoring of CAH due to 21-Hydroxylase deficiency.
Androstenedione is secreted predominately by the adrenal gland and production is at least partly controlled by ACTH. It is also produced ACTH-independent in the testes and ovaries from adrenalsecreted DHEAS. Androstenedione is a crucial sex-steroid precursor, moreover it is one of the most important tests for CAH screening.
Corticosterone is a steroid hormone and a precursor molecule for Aldosterone. It is the first intermediate in the mineralocorticoid pathway with significant mineral corticoid activity. Corticosterone is used for the diagnosis of suspected 11-Hydroxylase deficiency and Glucocorticoid-responsive hyperaldosteronism.
Dehydroepiandrosterone (DHEA) is secreted by the adrenal gland and production is at least partly controlled by ACTH. DHEA leads to the production of Androgens and Estrogens. DHEA production naturally peaks between 20-25 years of age and declines rapidly after age 25 years. Lower DHEA levels are found in people with hormonal disorders, HIV/AIDS, Alzheimer's disease, heart disease, depression, diabetes, inflammation, immune disorders, and osteoporosis.
N Health provides the Steroid Hormones testing in serum by using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) which is very high sensitivity and specificity.
*This operation schedule is for the test performed at N Health head quarter, Bangkok .
**Above turnaround time does not include logistic time. For BDMS network hospitals, please contact N Health laboratory located at your hospitals .
References: Clin Lab Med. 2004 March; 24(1): 105-118, http://www.mayomedicallaboratories.com