Health Articles

Our Clinical Laboratory Services cover diversified diagnoses that patients and physicians need in making healthcare decisions such as

N Test

14 February 2019

Hereditary Cancer



Cancer is an abnormality of cellular proliferation majorly caused by gene mutations. There are two types of gene mutations 
related to cancers. First, a mutation that occurs sporadically and can be found only in the affected cell, somatic mutations, this type of mutation cannot use for cancer risk assessment. On the other hand, the inheritable mutation named germline mutation that can be detected in most tissues of the body. This type of mutation is related to familial and hereditary cancers which increase the lifetime risk of developing cancer.

Some of the cancers have a high proportion of inheritable rate, for example, hereditary colorectal cancer, hereditary breast and ovarian cancer and prostate cancer. Hereditary cancers related germline mutations can be detected and interpreted from blood or saliva with Massive Parallel Sequencing and Bioinformatics.

Having hereditary cancer-related mutation does not mean an individual will get cancer. The individual is at a higher risk of developing a certain type or types of cancer compared compared to normal and should have more proactive screening and preventive for cancers such as colonoscopy, mammogram and tumor markers.

N Health provides hereditary cancer screening testing covered various types of cancers and numbers of genes including hereditary colorectal cancer and hereditary breast and ovarian cancer which have a higher rate of inheritable mutations.




*Above turnaround time does not include logistic time. For BDMS network hospitals, please contact N Health laboratory located at your hospitals.

References

1. Flynn S, Cusack G, Wallen GR. Integrating Genomics into Oncology Practice. InSeminars in Oncology Nursing 2019 Jan 24. WB Saunders.

2. National Comprehensive Cancer Network. Genetic/familial high-risk assessment: colorectal. NCCN Clinical Practice Guidelines in Oncology. Version. 2018; 1.

3. National Comprehensive Cancer Network. Genetic/familial high-risk assessment: breast and ovarian. NCCN Clinical Practice Guidelines in Oncology. Version. 2019; 1.

4. National Comprehensive Cancer Network. Prostate Cancer Early Detection. NCCN Clinical Practice Guidelines in Oncology. Version. 2019; 1.

BACK

N Test

10 June 2019

Steroid Hormones

Steroid hormones are derived from cholesterol and synthesized in the adrenal c...

MORE

N Test

22 May 2019

Syphilis

Syphilis is coming back again. Especially in adolescents, caused by having sex...

MORE

N Test

10 June 2019

Steroid Hormones

Steroid hormones are derived from cholesterol and synthesized in the adrenal c...

MORE

N Test

22 May 2019

Syphilis

Syphilis is coming back again. Especially in adolescents, caused by having sex...

MORE

N Test

14 May 2019

Biomarker of DNA damage:8-OHdG

8-OHdG is a biochemical product of DNA damage

MORE