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N Test

05 March 2019

Pre-Eclampsia



PRE-ECLAMPSIA
is a pregnancy complication; characterized by high blood pressure, higher than or equal to 140/90 millimeter of mercury (mm Hg) and is often a significant amount of protein in the urine. Various complications could affect both the mother and the fetus until death. Generally, this symptom occurs in pregnant women who are over 20 weeks of gestation until 48 hours after birth

In addition, pregnant women may occur severe complications; for example, seizures, renal failure, pulmonary edema, bleeding in different organs from thrombocytopenia and it could die. There are some complications with a baby; for example, babies’ growth is slower than normal, low birth-weight, premature and might die.

There is no definitive known cause of pre-eclampsia but assumed that it could be caused by the abnormal response in the mother's immune mechanism to pregnancy or heredity. The imbalance between proteins that promote vascular formation (PlGF; Placental Growth Factor) and proteins that inhibit blood vessel formation (sFlt-1: Soluble Fms-like Tyrosine Kinase-1) affect the malfunction of blood vessels to feed the placenta sufficiently. After the death of some placenta flesh, it is releasing substances to shrink blood vessels throughout the body of pregnant women.

At present, the risk assessment of pre-eclampsia screening has been conducted by PLGF; Placental Growth Factor together with evaluation in the history of pregnant women, gestational age, blood pressure measurement (Mean Arterial Pressure). Uterine Artery Doppler could be measured from the gestational age at least 11 weeks since there is no symptom of pre-eclampsia. Planning cure and prevention of these symptoms help doctors to find optimal treatment and reducing complications for mother and babies.



* This operation schedule is for the test performed at N Health head quarter, Bangkok .
** Above turnaround time does not include logistic time. For BDMS network hospitals, please contact N Health laboratory located at your hospitals.

References
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613/ Risk factors and effective management of preeclampsia
2 http://haamor.com/th/ครรภ์เป็นพิษ ครรภ์เป็นพิษ (Preeclampsia)

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