Tests and Procedures

Our Clinical Laboratory Services cover diversified diagnoses that patients and physicians need in making healthcare decisions such as

Find a test or procedure by its first letter

Find a test or procedure by its first letter

Find a test or procedure by its first letter

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

N502 : AMA / ASMA / anti-LKM

Comment

Test Code
N502
Test Name
AMA / ASMA / anti-LKM
Department
Immunology
Sample Type/Volume
serum 1 ml
Storage Condition
2-8 °C
Collection Remark
-
Principle
-
Method
IFA
Reference Range
-
Clinical

Anti-mitochondrial antibodies (AMA) occur in over 90% of primary biliary cirrhosis cases, 3-11% of
chronic active hepatitis patients and are absent in patients with extrahepatic biliary obstruction and in
other liver diseases. 

Anti-smooth muscle antibodies (ASMA) in high titer (>160) occur in the majority of cases of chronic
active hepatitis and in intermediate titers (40-80) in acute viral hepatitis. Occasionally they may occur in
cases of primary biliary cirrhosis where they are also found in intermediate titers. The significance of
titers of 20-40 is doubtful since these titers may occur in normal

Seropositivity for anti-LKM-1 antibodies is consistent with a diagnosis of Autoimmune Hepatitis (AIH) type 2. Anti-LKM-1 antibodies serve as a serologic marker for AIH type 2 and typically occur in the absence of ASMA and antinuclear antibodies. Patients with AIH type 2 more often tend to be young, female, and have severe disease that responds well to immunosuppressive therapy.
If the anti-LKM-1 test is negative, but ASMA and/or ANA  are positive, then the person likely has AIH type 1 



 

Turnaround Time
4 days
Operation Schedule
Mon ,Thu